Calbindin Gene in the Prostate Cell Line PC3 Subtractive Cloning of a Hybrid Human Endogenous Retrovirus

نویسندگان

  • Alvin Y. Liu
  • Barbara A. Abraham
چکیده

A complementary DNA clone containing human endogenous retrovirus-like sequences spliced to sequences encoding human calbindin was discovered by complementary DNA subtraction analysis between two human prostate cell lines, PC3 and DU145. This gene is presumably activated by the long terminal repeat of the retrovirus-like sequence. It belongs to a member of the retrovirus-like H (lKN V'" primer binding sequence) family. The level of this transcript is high in PC3, derived from a prostate bone metastasis, but not in DU 145, derived from a prostate brain metastasis.

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تاریخ انتشار 2006